- Improving 3D Imaging with Pre-Trained Perpendicular 2D Diffusion Models Diffusion models have become a popular approach for image generation and reconstruction due to their numerous advantages. However, most diffusion-based inverse problem-solving methods only deal with 2D images, and even recently published 3D methods do not fully exploit the 3D distribution prior. To address this, we propose a novel approach using two perpendicular pre-trained 2D diffusion models to solve the 3D inverse problem. By modeling the 3D data distribution as a product of 2D distributions sliced in different directions, our method effectively addresses the curse of dimensionality. Our experimental results demonstrate that our method is highly effective for 3D medical image reconstruction tasks, including MRI Z-axis super-resolution, compressed sensing MRI, and sparse-view CT. Our method can generate high-quality voxel volumes suitable for medical applications. 6 authors · Mar 15, 2023
- Atlas: End-to-End 3D Scene Reconstruction from Posed Images We present an end-to-end 3D reconstruction method for a scene by directly regressing a truncated signed distance function (TSDF) from a set of posed RGB images. Traditional approaches to 3D reconstruction rely on an intermediate representation of depth maps prior to estimating a full 3D model of a scene. We hypothesize that a direct regression to 3D is more effective. A 2D CNN extracts features from each image independently which are then back-projected and accumulated into a voxel volume using the camera intrinsics and extrinsics. After accumulation, a 3D CNN refines the accumulated features and predicts the TSDF values. Additionally, semantic segmentation of the 3D model is obtained without significant computation. This approach is evaluated on the Scannet dataset where we significantly outperform state-of-the-art baselines (deep multiview stereo followed by traditional TSDF fusion) both quantitatively and qualitatively. We compare our 3D semantic segmentation to prior methods that use a depth sensor since no previous work attempts the problem with only RGB input. 6 authors · Mar 23, 2020
1 SiM3D: Single-instance Multiview Multimodal and Multisetup 3D Anomaly Detection Benchmark We propose SiM3D, the first benchmark considering the integration of multiview and multimodal information for comprehensive 3D anomaly detection and segmentation (ADS), where the task is to produce a voxel-based Anomaly Volume. Moreover, SiM3D focuses on a scenario of high interest in manufacturing: single-instance anomaly detection, where only one object, either real or synthetic, is available for training. In this respect, SiM3D stands out as the first ADS benchmark that addresses the challenge of generalising from synthetic training data to real test data. SiM3D includes a novel multimodal multiview dataset acquired using top-tier industrial sensors and robots. The dataset features multiview high-resolution images (12 Mpx) and point clouds (7M points) for 333 instances of eight types of objects, alongside a CAD model for each type. We also provide manually annotated 3D segmentation GTs for anomalous test samples. To establish reference baselines for the proposed multiview 3D ADS task, we adapt prominent singleview methods and assess their performance using novel metrics that operate on Anomaly Volumes. 7 authors · Jun 26, 2025
43 Voxify3D: Pixel Art Meets Volumetric Rendering Voxel art is a distinctive stylization widely used in games and digital media, yet automated generation from 3D meshes remains challenging due to conflicting requirements of geometric abstraction, semantic preservation, and discrete color coherence. Existing methods either over-simplify geometry or fail to achieve the pixel-precise, palette-constrained aesthetics of voxel art. We introduce Voxify3D, a differentiable two-stage framework bridging 3D mesh optimization with 2D pixel art supervision. Our core innovation lies in the synergistic integration of three components: (1) orthographic pixel art supervision that eliminates perspective distortion for precise voxel-pixel alignment; (2) patch-based CLIP alignment that preserves semantics across discretization levels; (3) palette-constrained Gumbel-Softmax quantization enabling differentiable optimization over discrete color spaces with controllable palette strategies. This integration addresses fundamental challenges: semantic preservation under extreme discretization, pixel-art aesthetics through volumetric rendering, and end-to-end discrete optimization. Experiments show superior performance (37.12 CLIP-IQA, 77.90\% user preference) across diverse characters and controllable abstraction (2-8 colors, 20x-50x resolutions). Project page: https://yichuanh.github.io/Voxify-3D/ 4 authors · Dec 8, 2025 2
- Direct Voxel Grid Optimization: Super-fast Convergence for Radiance Fields Reconstruction We present a super-fast convergence approach to reconstructing the per-scene radiance field from a set of images that capture the scene with known poses. This task, which is often applied to novel view synthesis, is recently revolutionized by Neural Radiance Field (NeRF) for its state-of-the-art quality and flexibility. However, NeRF and its variants require a lengthy training time ranging from hours to days for a single scene. In contrast, our approach achieves NeRF-comparable quality and converges rapidly from scratch in less than 15 minutes with a single GPU. We adopt a representation consisting of a density voxel grid for scene geometry and a feature voxel grid with a shallow network for complex view-dependent appearance. Modeling with explicit and discretized volume representations is not new, but we propose two simple yet non-trivial techniques that contribute to fast convergence speed and high-quality output. First, we introduce the post-activation interpolation on voxel density, which is capable of producing sharp surfaces in lower grid resolution. Second, direct voxel density optimization is prone to suboptimal geometry solutions, so we robustify the optimization process by imposing several priors. Finally, evaluation on five inward-facing benchmarks shows that our method matches, if not surpasses, NeRF's quality, yet it only takes about 15 minutes to train from scratch for a new scene. 3 authors · Nov 22, 2021
6 VoMP: Predicting Volumetric Mechanical Property Fields Physical simulation relies on spatially-varying mechanical properties, often laboriously hand-crafted. VoMP is a feed-forward method trained to predict Young's modulus (E), Poisson's ratio (nu), and density (rho) throughout the volume of 3D objects, in any representation that can be rendered and voxelized. VoMP aggregates per-voxel multi-view features and passes them to our trained Geometry Transformer to predict per-voxel material latent codes. These latents reside on a manifold of physically plausible materials, which we learn from a real-world dataset, guaranteeing the validity of decoded per-voxel materials. To obtain object-level training data, we propose an annotation pipeline combining knowledge from segmented 3D datasets, material databases, and a vision-language model, along with a new benchmark. Experiments show that VoMP estimates accurate volumetric properties, far outperforming prior art in accuracy and speed. NVIDIA · Oct 26, 2025 1
- Deep Volumetric Ambient Occlusion We present a novel deep learning based technique for volumetric ambient occlusion in the context of direct volume rendering. Our proposed Deep Volumetric Ambient Occlusion (DVAO) approach can predict per-voxel ambient occlusion in volumetric data sets, while considering global information provided through the transfer function. The proposed neural network only needs to be executed upon change of this global information, and thus supports real-time volume interaction. Accordingly, we demonstrate DVAOs ability to predict volumetric ambient occlusion, such that it can be applied interactively within direct volume rendering. To achieve the best possible results, we propose and analyze a variety of transfer function representations and injection strategies for deep neural networks. Based on the obtained results we also give recommendations applicable in similar volume learning scenarios. Lastly, we show that DVAO generalizes to a variety of modalities, despite being trained on computed tomography data only. 2 authors · Aug 19, 2020
- Vox-E: Text-guided Voxel Editing of 3D Objects Large scale text-guided diffusion models have garnered significant attention due to their ability to synthesize diverse images that convey complex visual concepts. This generative power has more recently been leveraged to perform text-to-3D synthesis. In this work, we present a technique that harnesses the power of latent diffusion models for editing existing 3D objects. Our method takes oriented 2D images of a 3D object as input and learns a grid-based volumetric representation of it. To guide the volumetric representation to conform to a target text prompt, we follow unconditional text-to-3D methods and optimize a Score Distillation Sampling (SDS) loss. However, we observe that combining this diffusion-guided loss with an image-based regularization loss that encourages the representation not to deviate too strongly from the input object is challenging, as it requires achieving two conflicting goals while viewing only structure-and-appearance coupled 2D projections. Thus, we introduce a novel volumetric regularization loss that operates directly in 3D space, utilizing the explicit nature of our 3D representation to enforce correlation between the global structure of the original and edited object. Furthermore, we present a technique that optimizes cross-attention volumetric grids to refine the spatial extent of the edits. Extensive experiments and comparisons demonstrate the effectiveness of our approach in creating a myriad of edits which cannot be achieved by prior works. 4 authors · Mar 21, 2023
- High-fidelity 3D Object Generation from Single Image with RGBN-Volume Gaussian Reconstruction Model Recently single-view 3D generation via Gaussian splatting has emerged and developed quickly. They learn 3D Gaussians from 2D RGB images generated from pre-trained multi-view diffusion (MVD) models, and have shown a promising avenue for 3D generation through a single image. Despite the current progress, these methods still suffer from the inconsistency jointly caused by the geometric ambiguity in the 2D images, and the lack of structure of 3D Gaussians, leading to distorted and blurry 3D object generation. In this paper, we propose to fix these issues by GS-RGBN, a new RGBN-volume Gaussian Reconstruction Model designed to generate high-fidelity 3D objects from single-view images. Our key insight is a structured 3D representation can simultaneously mitigate the afore-mentioned two issues. To this end, we propose a novel hybrid Voxel-Gaussian representation, where a 3D voxel representation contains explicit 3D geometric information, eliminating the geometric ambiguity from 2D images. It also structures Gaussians during learning so that the optimization tends to find better local optima. Our 3D voxel representation is obtained by a fusion module that aligns RGB features and surface normal features, both of which can be estimated from 2D images. Extensive experiments demonstrate the superiority of our methods over prior works in terms of high-quality reconstruction results, robust generalization, and good efficiency. 5 authors · Apr 2, 2025
- Learning General-Purpose Biomedical Volume Representations using Randomized Synthesis Current volumetric biomedical foundation models struggle to generalize as public 3D datasets are small and do not cover the broad diversity of medical procedures, conditions, anatomical regions, and imaging protocols. We address this by creating a representation learning method that instead anticipates strong domain shifts at training time itself. We first propose a data engine that synthesizes highly variable training samples that would enable generalization to new biomedical contexts. To then train a single 3D network for any voxel-level task, we develop a contrastive learning method that pretrains the network to be stable against nuisance imaging variation simulated by the data engine, a key inductive bias for generalization. This network's features can be used as robust representations of input images for downstream tasks and its weights provide a strong, dataset-agnostic initialization for finetuning on new datasets. As a result, we set new standards across both multimodality registration and few-shot segmentation, a first for any 3D biomedical vision model, all without (pre-)training on any existing dataset of real images. 8 authors · Nov 4, 2024
- Leveraging Semantic Asymmetry for Precise Gross Tumor Volume Segmentation of Nasopharyngeal Carcinoma in Planning CT In the radiation therapy of nasopharyngeal carcinoma (NPC), clinicians typically delineate the gross tumor volume (GTV) using non-contrast planning computed tomography to ensure accurate radiation dose delivery. However, the low contrast between tumors and adjacent normal tissues necessitates that radiation oncologists manually delineate the tumors, often relying on diagnostic MRI for guidance. % In this study, we propose a novel approach to directly segment NPC gross tumors on non-contrast planning CT images, circumventing potential registration errors when aligning MRI or MRI-derived tumor masks to planning CT. To address the low contrast issues between tumors and adjacent normal structures in planning CT, we introduce a 3D Semantic Asymmetry Tumor segmentation (SATs) method. Specifically, we posit that a healthy nasopharyngeal region is characteristically bilaterally symmetric, whereas the emergence of nasopharyngeal carcinoma disrupts this symmetry. Then, we propose a Siamese contrastive learning segmentation framework that minimizes the voxel-wise distance between original and flipped areas without tumor and encourages a larger distance between original and flipped areas with tumor. Thus, our approach enhances the sensitivity of features to semantic asymmetries. % Extensive experiments demonstrate that the proposed SATs achieves the leading NPC GTV segmentation performance in both internal and external testing, e.g., with at least 2\% absolute Dice score improvement and 12\% average distance error reduction when compared to other state-of-the-art methods in the external testing. 15 authors · Nov 27, 2024
- FaVoR: Features via Voxel Rendering for Camera Relocalization Camera relocalization methods range from dense image alignment to direct camera pose regression from a query image. Among these, sparse feature matching stands out as an efficient, versatile, and generally lightweight approach with numerous applications. However, feature-based methods often struggle with significant viewpoint and appearance changes, leading to matching failures and inaccurate pose estimates. To overcome this limitation, we propose a novel approach that leverages a globally sparse yet locally dense 3D representation of 2D features. By tracking and triangulating landmarks over a sequence of frames, we construct a sparse voxel map optimized to render image patch descriptors observed during tracking. Given an initial pose estimate, we first synthesize descriptors from the voxels using volumetric rendering and then perform feature matching to estimate the camera pose. This methodology enables the generation of descriptors for unseen views, enhancing robustness to view changes. We extensively evaluate our method on the 7-Scenes and Cambridge Landmarks datasets. Our results show that our method significantly outperforms existing state-of-the-art feature representation techniques in indoor environments, achieving up to a 39% improvement in median translation error. Additionally, our approach yields comparable results to other methods for outdoor scenarios while maintaining lower memory and computational costs. 4 authors · Sep 11, 2024
- VoxFormer: Sparse Voxel Transformer for Camera-based 3D Semantic Scene Completion Humans can easily imagine the complete 3D geometry of occluded objects and scenes. This appealing ability is vital for recognition and understanding. To enable such capability in AI systems, we propose VoxFormer, a Transformer-based semantic scene completion framework that can output complete 3D volumetric semantics from only 2D images. Our framework adopts a two-stage design where we start from a sparse set of visible and occupied voxel queries from depth estimation, followed by a densification stage that generates dense 3D voxels from the sparse ones. A key idea of this design is that the visual features on 2D images correspond only to the visible scene structures rather than the occluded or empty spaces. Therefore, starting with the featurization and prediction of the visible structures is more reliable. Once we obtain the set of sparse queries, we apply a masked autoencoder design to propagate the information to all the voxels by self-attention. Experiments on SemanticKITTI show that VoxFormer outperforms the state of the art with a relative improvement of 20.0% in geometry and 18.1% in semantics and reduces GPU memory during training to less than 16GB. Our code is available on https://github.com/NVlabs/VoxFormer. 8 authors · Feb 23, 2023
- PFDepth: Heterogeneous Pinhole-Fisheye Joint Depth Estimation via Distortion-aware Gaussian-Splatted Volumetric Fusion In this paper, we present the first pinhole-fisheye framework for heterogeneous multi-view depth estimation, PFDepth. Our key insight is to exploit the complementary characteristics of pinhole and fisheye imagery (undistorted vs. distorted, small vs. large FOV, far vs. near field) for joint optimization. PFDepth employs a unified architecture capable of processing arbitrary combinations of pinhole and fisheye cameras with varied intrinsics and extrinsics. Within PFDepth, we first explicitly lift 2D features from each heterogeneous view into a canonical 3D volumetric space. Then, a core module termed Heterogeneous Spatial Fusion is designed to process and fuse distortion-aware volumetric features across overlapping and non-overlapping regions. Additionally, we subtly reformulate the conventional voxel fusion into a novel 3D Gaussian representation, in which learnable latent Gaussian spheres dynamically adapt to local image textures for finer 3D aggregation. Finally, fused volume features are rendered into multi-view depth maps. Through extensive experiments, we demonstrate that PFDepth sets a state-of-the-art performance on KITTI-360 and RealHet datasets over current mainstream depth networks. To the best of our knowledge, this is the first systematic study of heterogeneous pinhole-fisheye depth estimation, offering both technical novelty and valuable empirical insights. 8 authors · Sep 30, 2025
- Boosting Multi-View Indoor 3D Object Detection via Adaptive 3D Volume Construction This work presents SGCDet, a novel multi-view indoor 3D object detection framework based on adaptive 3D volume construction. Unlike previous approaches that restrict the receptive field of voxels to fixed locations on images, we introduce a geometry and context aware aggregation module to integrate geometric and contextual information within adaptive regions in each image and dynamically adjust the contributions from different views, enhancing the representation capability of voxel features. Furthermore, we propose a sparse volume construction strategy that adaptively identifies and selects voxels with high occupancy probabilities for feature refinement, minimizing redundant computation in free space. Benefiting from the above designs, our framework achieves effective and efficient volume construction in an adaptive way. Better still, our network can be supervised using only 3D bounding boxes, eliminating the dependence on ground-truth scene geometry. Experimental results demonstrate that SGCDet achieves state-of-the-art performance on the ScanNet, ScanNet200 and ARKitScenes datasets. The source code is available at https://github.com/RM-Zhang/SGCDet. 7 authors · Jul 24, 2025
- 3D ShapeNets: A Deep Representation for Volumetric Shapes 3D shape is a crucial but heavily underutilized cue in today's computer vision systems, mostly due to the lack of a good generic shape representation. With the recent availability of inexpensive 2.5D depth sensors (e.g. Microsoft Kinect), it is becoming increasingly important to have a powerful 3D shape representation in the loop. Apart from category recognition, recovering full 3D shapes from view-based 2.5D depth maps is also a critical part of visual understanding. To this end, we propose to represent a geometric 3D shape as a probability distribution of binary variables on a 3D voxel grid, using a Convolutional Deep Belief Network. Our model, 3D ShapeNets, learns the distribution of complex 3D shapes across different object categories and arbitrary poses from raw CAD data, and discovers hierarchical compositional part representations automatically. It naturally supports joint object recognition and shape completion from 2.5D depth maps, and it enables active object recognition through view planning. To train our 3D deep learning model, we construct ModelNet -- a large-scale 3D CAD model dataset. Extensive experiments show that our 3D deep representation enables significant performance improvement over the-state-of-the-arts in a variety of tasks. 7 authors · Jun 21, 2014
- PVSeRF: Joint Pixel-, Voxel- and Surface-Aligned Radiance Field for Single-Image Novel View Synthesis We present PVSeRF, a learning framework that reconstructs neural radiance fields from single-view RGB images, for novel view synthesis. Previous solutions, such as pixelNeRF, rely only on pixel-aligned features and suffer from feature ambiguity issues. As a result, they struggle with the disentanglement of geometry and appearance, leading to implausible geometries and blurry results. To address this challenge, we propose to incorporate explicit geometry reasoning and combine it with pixel-aligned features for radiance field prediction. Specifically, in addition to pixel-aligned features, we further constrain the radiance field learning to be conditioned on i) voxel-aligned features learned from a coarse volumetric grid and ii) fine surface-aligned features extracted from a regressed point cloud. We show that the introduction of such geometry-aware features helps to achieve a better disentanglement between appearance and geometry, i.e. recovering more accurate geometries and synthesizing higher quality images of novel views. Extensive experiments against state-of-the-art methods on ShapeNet benchmarks demonstrate the superiority of our approach for single-image novel view synthesis. 7 authors · Feb 10, 2022
- DynaVol: Unsupervised Learning for Dynamic Scenes through Object-Centric Voxelization Unsupervised learning of object-centric representations in dynamic visual scenes is challenging. Unlike most previous approaches that learn to decompose 2D images, we present DynaVol, a 3D scene generative model that unifies geometric structures and object-centric learning in a differentiable volume rendering framework. The key idea is to perform object-centric voxelization to capture the 3D nature of the scene, which infers the probability distribution over objects at individual spatial locations. These voxel features evolve over time through a canonical-space deformation function, forming the basis for global representation learning via slot attention. The voxel features and global features are complementary and are both leveraged by a compositional NeRF decoder for volume rendering. DynaVol remarkably outperforms existing approaches for unsupervised dynamic scene decomposition. Once trained, the explicitly meaningful voxel features enable additional capabilities that 2D scene decomposition methods cannot achieve: it is possible to freely edit the geometric shapes or manipulate the motion trajectories of the objects. 4 authors · Apr 30, 2023
- MAISI: Medical AI for Synthetic Imaging Medical imaging analysis faces challenges such as data scarcity, high annotation costs, and privacy concerns. This paper introduces the Medical AI for Synthetic Imaging (MAISI), an innovative approach using the diffusion model to generate synthetic 3D computed tomography (CT) images to address those challenges. MAISI leverages the foundation volume compression network and the latent diffusion model to produce high-resolution CT images (up to a landmark volume dimension of 512 x 512 x 768 ) with flexible volume dimensions and voxel spacing. By incorporating ControlNet, MAISI can process organ segmentation, including 127 anatomical structures, as additional conditions and enables the generation of accurately annotated synthetic images that can be used for various downstream tasks. Our experiment results show that MAISI's capabilities in generating realistic, anatomically accurate images for diverse regions and conditions reveal its promising potential to mitigate challenges using synthetic data. 11 authors · Sep 13, 2024
- UniArt: Unified 3D Representation for Generating 3D Articulated Objects with Open-Set Articulation Articulated 3D objects play a vital role in realistic simulation and embodied robotics, yet manually constructing such assets remains costly and difficult to scale. In this paper, we present UniArt, a diffusion-based framework that directly synthesizes fully articulated 3D objects from a single image in an end-to-end manner. Unlike prior multi-stage techniques, UniArt establishes a unified latent representation that jointly encodes geometry, texture, part segmentation, and kinematic parameters. We introduce a reversible joint-to-voxel embedding, which spatially aligns articulation features with volumetric geometry, enabling the model to learn coherent motion behaviors alongside structural formation. Furthermore, we formulate articulation type prediction as an open-set problem, removing the need for fixed joint semantics and allowing generalization to novel joint categories and unseen object types. Experiments on the PartNet-Mobility benchmark demonstrate that UniArt achieves state-of-the-art mesh quality and articulation accuracy. 7 authors · Nov 26, 2025
- Sparse Voxels Rasterization: Real-time High-fidelity Radiance Field Rendering We propose an efficient radiance field rendering algorithm that incorporates a rasterization process on adaptive sparse voxels without neural networks or 3D Gaussians. There are two key contributions coupled with the proposed system. The first is to adaptively and explicitly allocate sparse voxels to different levels of detail within scenes, faithfully reproducing scene details with 65536^3 grid resolution while achieving high rendering frame rates. Second, we customize a rasterizer for efficient adaptive sparse voxels rendering. We render voxels in the correct depth order by using ray direction-dependent Morton ordering, which avoids the well-known popping artifact found in Gaussian splatting. Our method improves the previous neural-free voxel model by over 4db PSNR and more than 10x FPS speedup, achieving state-of-the-art comparable novel-view synthesis results. Additionally, our voxel representation is seamlessly compatible with grid-based 3D processing techniques such as Volume Fusion, Voxel Pooling, and Marching Cubes, enabling a wide range of future extensions and applications. 5 authors · Dec 5, 2024
- GaussianOcc: Fully Self-supervised and Efficient 3D Occupancy Estimation with Gaussian Splatting We introduce GaussianOcc, a systematic method that investigates the two usages of Gaussian splatting for fully self-supervised and efficient 3D occupancy estimation in surround views. First, traditional methods for self-supervised 3D occupancy estimation still require ground truth 6D poses from sensors during training. To address this limitation, we propose Gaussian Splatting for Projection (GSP) module to provide accurate scale information for fully self-supervised training from adjacent view projection. Additionally, existing methods rely on volume rendering for final 3D voxel representation learning using 2D signals (depth maps, semantic maps), which is both time-consuming and less effective. We propose Gaussian Splatting from Voxel space (GSV) to leverage the fast rendering properties of Gaussian splatting. As a result, the proposed GaussianOcc method enables fully self-supervised (no ground truth pose) 3D occupancy estimation in competitive performance with low computational cost (2.7 times faster in training and 5 times faster in rendering). The relevant code is available in https://github.com/GANWANSHUI/GaussianOcc.git. 5 authors · Aug 21, 2024
- Extremely weakly-supervised blood vessel segmentation with physiologically based synthesis and domain adaptation Accurate analysis and modeling of renal functions require a precise segmentation of the renal blood vessels. Micro-CT scans provide image data at higher resolutions, making more small vessels near the renal cortex visible. Although deep-learning-based methods have shown state-of-the-art performance in automatic blood vessel segmentations, they require a large amount of labeled training data. However, voxel-wise labeling in micro-CT scans is extremely time-consuming given the huge volume sizes. To mitigate the problem, we simulate synthetic renal vascular trees physiologically while generating corresponding scans of the simulated trees by training a generative model on unlabeled scans. This enables the generative model to learn the mapping implicitly without the need for explicit functions to emulate the image acquisition process. We further propose an additional segmentation branch over the generative model trained on the generated scans. We demonstrate that the model can directly segment blood vessels on real scans and validate our method on both 3D micro-CT scans of rat kidneys and a proof-of-concept experiment on 2D retinal images. Code and 3D results are available at https://github.com/miccai2023anony/RenalVesselSeg 5 authors · May 26, 2023
- MIS-FM: 3D Medical Image Segmentation using Foundation Models Pretrained on a Large-Scale Unannotated Dataset Pretraining with large-scale 3D volumes has a potential for improving the segmentation performance on a target medical image dataset where the training images and annotations are limited. Due to the high cost of acquiring pixel-level segmentation annotations on the large-scale pretraining dataset, pretraining with unannotated images is highly desirable. In this work, we propose a novel self-supervised learning strategy named Volume Fusion (VF) for pretraining 3D segmentation models. It fuses several random patches from a foreground sub-volume to a background sub-volume based on a predefined set of discrete fusion coefficients, and forces the model to predict the fusion coefficient of each voxel, which is formulated as a self-supervised segmentation task without manual annotations. Additionally, we propose a novel network architecture based on parallel convolution and transformer blocks that is suitable to be transferred to different downstream segmentation tasks with various scales of organs and lesions. The proposed model was pretrained with 110k unannotated 3D CT volumes, and experiments with different downstream segmentation targets including head and neck organs, thoracic/abdominal organs showed that our pretrained model largely outperformed training from scratch and several state-of-the-art self-supervised training methods and segmentation models. The code and pretrained model are available at https://github.com/openmedlab/MIS-FM. 6 authors · Jun 29, 2023