﻿ Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives | Bentham Science
Author(s): Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira, Wilson Cunico. Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil.
DOI : 10.2174/15734064113099990030
Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
Keywords: Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Title:Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives
Author(s):Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira and Wilson Cunico
Affiliation:Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil.
Keywords:Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Abstract:Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira and Wilson Cunico, “Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives”, Medicinal Chemistry (2014) 10: 355. https://doi.org/10.2174/15734064113099990030
https://doi.org/10.2174/15734064113099990030 Print ISSN
﻿ Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives | Bentham Science
Author(s): Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira, Wilson Cunico. Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil.
DOI : 10.2174/15734064113099990030
Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
Keywords: Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Title:Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives
Author(s):Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabi
o R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira and Wilson Cunico
Affiliation:Universidade Federal de Pelotas, CCQFA, R. Gomes Carneiro 1, caixa postal 354, CEP: 96001-970, Brazil.
Keywords:Antifungal activity, cytotoxic activity, Rhodotorula, thiazolidinones.
Abstract:Thiazolidinones, synthesized from multicomponent reactions of 2-heteroarylmethylamine, arenealdehydes and mercaptoacetic acid, have been tested against six yeasts, namely Candida albicans, C. parapsilosis, C. guilliermondii, Cryptococcus laurentii, Trichosporon asahii and Rhodotorula spp. The activities were expressed as minimum inhibitory concentrations (MIC) and the minimum fungicidal concentrations (MFC). The most affected yeasts were Rhodotorula spp and T. asahii. The cytotoxicities of the thiazolidinones against the fibroblast 3T3/NIH cell line are also described. The antifungal results and the low cytotoxicity of the compounds in this work provide good guides for the further development of active compounds.
Gabriela H. Marques, Alice Kunzler, Valeria D.O. Bareno, Bruna B. Drawanz, Hellen G. Mastelloto, Fabio R.M. Leite, Gustavo G. Nascimento, Patrícia S. Nascente, Geonir M. Siqueira and Wilson Cunico, “Antifungal Activity of 3-(heteroaryl-2-ylmethyl)thiazolidinone Derivatives”, Medicinal Chemistry (2014) 10: 355. https://doi.org/10.2174/15734064113099990030
https://doi.org/10.2174/15734064113099990030 Print ISSN