ZNF383 - Zinc finger protein 383 - Homo sapiens (Human) - ZNF383 gene & protein
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(ZN383_HUMAN)Basket 0(max 400 entries)xYour basket is currently empty.Select item(s) and click on "Add to basket" to create your own collection here (400 entries max)UniProtKB (0)UniRef (0)UniParc (0)AlignBLASTMap IdsDownloadFull ViewRemoveClear DisplayEntryPublicationsFeature viewerFeature tableAll NoneFunctionNames & TaxonomySubcellular locationSubcell. locationPathology & BiotechPathol./BiotechPTM / ProcessingExpressionInteractionStructureFamily & DomainsSequenceCross-referencesEntry informationMiscellaneousSimilar proteinsTopBLAST>sp|Q8NA42|ZN383_HUMAN Zinc finger protein 383 OS=Homo sapiens GN=ZNF383 PE=2 SV=1
MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQ
GKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDV
LEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFS
QNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSY
LSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQH
ARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIH
TGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEK
PYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK
AlignFormatAdd to basketAdded to basketHistoryEntry version 121 (30 Nov 2016)Sequence version 1 (01 Oct 2002)Previous versions | rssOther tutorials and videosHelp videoFeedbackProteinZinc finger protein 383GeneZNF383OrganismHomo sapiens (Human)StatusReviewed-Annotation score: Annotation score: 4 out of 5Annotation score:4 out of 5
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>FunctioniMay function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.RegionsFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotation
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotation
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>KeywordsiMolecular functionDNA-bindingBiological processTranscription, Transcription regulationLigandMetal-binding, ZincEnzyme and pathway databasesBioCyc Collection of Pathway/Genome DatabasesMore...BioCyciZFISH:ENSG00000066263-MONOMER. Reactome - a knowledgebase of biological pathways and processesMore...ReactomeiR-HSA-212436. Generic Transcription Pathway. <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the ‘Names and Taxonomy’ section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesiRecommended name:Zinc finger protein 383
<p>This subsection of the ‘Names and taxonomy’ section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesiName:ZNF383ORF Names:HSD17
<p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins. <br></br>These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19 Organism-specific databasesHuman Gene Nomenclature DatabaseMore...HGNCiHGNC:18609. ZNF383. <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationiNucleus 1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Cytoplasm 1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Note: Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenticytoplasm Source: UniProtKB-SubCellnuclear membrane Source: HPAnucleus Source: HPA
<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & BiotechiOrganism-specific databasesOpen TargetsMore...OpenTargetsiENSG00000188283. The Pharmacogenetics and Pharmacogenomics Knowledge BaseMore...PharmGKBiPA134903145. Polymorphism and mutation databasesBioMuta curated single-nucleotide variation and disease association databaseMore...BioMutaiZNF383. Domain mapping of disease mutations (DMDM)More...DMDMi74760056. <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475501 – 475Zinc finger protein 383Add BLAST475Proteomic databasesMaxQB - The MaxQuant DataBaseMore...MaxQBiQ8NA42. PaxDb, a database of protein abundance averages across all three domains of lifeMore...PaxDbiQ8NA42. PeptideAtlasMore...PeptideAtlasiQ8NA42. PRoteomics IDEntifications databaseMore...PRIDEiQ8NA42. PTM databasesiPTMnet integrated resource for PTMs in systems biology contextMore...iPTMnetiQ8NA42. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.More...PhosphoSitePlusiQ8NA42. <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityiExpressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageiIn tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Gene expression databasesBgee dataBase for Gene Expression EvolutionMore...BgeeiENSG00000188283. CleanEx database of gene expression profilesMore...CleanExiHS_ZNF383. ExpressionAtlas, Differential and Baseline ExpressionMore...ExpressionAtlasiQ8NA42. baseline and differential. Genevisible search portal to normalized and curated expression data from GenevestigatorMore...GenevisibleiQ8NA42. HS. Organism-specific databasesHuman Protein AtlasMore...HPAiHPA063945. <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>InteractioniProtein-protein interaction databasesThe Biological General Repository for Interaction Datasets (BioGrid)More...BioGridi127849. 2 interactors.STRING: functional protein association networksMore...STRINGi9606.ENSP00000340132. <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei3D structure databasesProtein Model Portal of the PSI-Nature Structural Biology KnowledgebaseMore...ProteinModelPortaliQ8NA42. SWISS-MODEL Repository - a database of annotated 3D protein structure modelsMore...SMRiQ8NA42. Database of comparative protein structure modelsMore...ModBaseiSearch...MobiDB: a database of protein disorder and mobility annotationsMore...MobiDBiSearch...
<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>DomainiThe KRAB domain is responsible for the transcriptional repressor activity.
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - DomainiRepeat, Zinc-fingerPhylogenomic databasesevolutionary genealogy of genes: Non-supervised Orthologous GroupsMore...eggNOGiKOG1721. Eukaryota. COG5048. LUCA. Ensembl GeneTreeMore...GeneTreeiENSGT00840000129704. The HOGENOM Database of Homologous Genes from Fully Sequenced OrganismsMore...HOGENOMiHOG000234617. The HOVERGEN Database of Homologous Vertebrate GenesMore...HOVERGENiHBG018163. InParanoid: Eukaryotic Ortholog GroupsMore...InParanoidiQ8NA42. KEGG Orthology (KO)More...KOiK09228. Identification of Orthologs from Complete Genome DataMore...OMAiLEYRNHF. Database of Orthologous GroupsMore...OrthoDBiEOG091G02KC. Database for complete collections of gene phylogeniesMore...PhylomeDBiQ8NA42. Family and domain databasesConserved Domains DatabaseMore...CDDicd07765. KRAB_A-box. 1 hit. Gene3D Structural and Functional Annotation of Protein FamiliesMore...Gene3Di3.30.160.60. 11 hits. Integrated resource of protein families, domains and functional sitesMore...InterProiIPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]Pfam protein domain databaseMore...PfamiPF01352. KRAB. 1 hit. PF00096. zf-C2H2. 7 hits. PF13465. zf-H2C2_2. 1 hit. [Graphical view]Simple Modular Architecture Research Tool; a protein domain databaseMore...SMARTiSM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]Superfamily database of structural and functional annotationMore...SUPFAMiSSF109640. SSF109640. 1 hit. PROSITE; a protein domain and family databaseMore...PROSITEiPS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.Q8NA42-1 [UniParc]FASTAAdd to basketAdded to basket« Hide        10         20         30         40         50MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP         60         70         80         90        100KPQVISLLEQ GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC        110        120        130        140        150QREIMGLTKH GLEYSSFGDV LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT        160        170        180        190        200FIQQTFLTLH QIINNEDRPY ECKKCGKAFS QNSQFIQHQR IHIGEKSYEC        210        220        230        240        250KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY LSQHQRIHTG        260        270        280        290        300KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH        310        320        330        340        350ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG        360        370        380        390        400SALTNHQRIH TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG        410        420        430        440        450KAFTQNSQLF QHQRIHTDEK PYECNECGKA FNKCSNLTRH LRIHTGEKPY        460        470 NCKECGKAFS SGSDLIRHQG IHTNK                       Show »Length:475Mass (Da):54,613Last modified:October 1, 2002 - v1
Checksum:i2F47070F5C2E582BBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterGOExperimental InfoFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11V → A in AAP20067 (Ref. 2) Curated1
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114Y → H in AAP20067 (Ref. 2) Curated1
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti443I → V in AAP20067 (Ref. 2) Curated1Sequence databasesSelect the link destinations:EMBL nucleotide sequence databaseMore...EMBLiGenBank nucleotide sequence databaseMore...GenBankiDNA Data Bank of Japan; a nucleotide sequence databaseMore...DDBJiLinks UpdatedAY438646 mRNA. Translation: AAR14184.1.AY260141 mRNA. Translation: AAP20067.1.AK093182 mRNA. Translation: BAC04086.1.The Consensus CDS (CCDS) projectMore...CCDSiCCDS12501.1. NCBI Reference SequencesMore...RefSeqiNP_689817.1. NM_152604.2. XP_005258642.1. XM_005258585.2. XP_011524888.1. XM_011526586.2. XP_011524889.1. XM_011526587.2. XP_011524890.1. XM_011526588.2. XP_011524891.1. XM_011526589.2. XP_011524892.1. XM_011526590.2. XP_016881911.1. XM_017026422.1. XP_016881912.1. XM_017026423.1. XP_016881913.1. XM_017026424.1. UniGene gene-oriented nucleotide sequence clustersMore...UniGeneiHs.590975. Genome annotation databasesEnsembl eukaryotic genome annotation projectMore...EnsembliENST00000352998; ENSP00000340132; ENSG00000188283. ENST00000589413; ENSP00000464871; ENSG00000188283. ENST00000590503; ENSP00000466101; ENSG00000188283. Database of genes from NCBI RefSeq genomesMore...GeneIDi163087. KEGG: Kyoto Encyclopedia of Genes and GenomesMore...KEGGihsa:163087. UCSC genome browserMore...UCSCiuc002oft.2. human. <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesiSequence databasesSelect the link destinations:EMBL nucleotide sequence databaseMore...EMBLiGenBank nucleotide sequence databaseMore...GenBankiDNA Data Bank of Japan; a nucleotide sequence databaseMore...DDBJiLinks UpdatedAY438646 mRNA. Translation: AAR14184.1.AY260141 mRNA. Translation: AAP20067.1.AK093182 mRNA. Translation: BAC04086.1.The Consensus CDS (CCDS) projectMore...CCDSiCCDS12501.1. NCBI Reference SequencesMore...RefSeqiNP_689817.1. NM_152604.2. XP_005258642.1. XM_005258585.2. XP_011524888.1. XM_011526586.2. XP_011524889.1. XM_011526587.2. XP_011524890.1. XM_011526588.2. XP_011524891.1. XM_011526589.2. XP_011524892.1. XM_011526590.2. XP_016881911.1. XM_017026422.1. XP_016881912.1. XM_017026423.1. XP_016881913.1. XM_017026424.1. UniGene gene-oriented nucleotide sequence clustersMore...UniGeneiHs.590975. 3D structure databasesProtein Model Portal of the PSI-Nature Structural Biology KnowledgebaseMore...ProteinModelPortaliQ8NA42. SWISS-MODEL Repository - a database of annotated 3D protein structure modelsMore...SMRiQ8NA42. Database of comparative protein structure modelsMore...ModBaseiSearch...MobiDB: a database of protein disorder and mobility annotationsMore...MobiDBiSearch...Protein-protein interaction databasesThe Biological General Repository for Interaction Datasets (BioGrid)More...BioGridi127849. 2 interactors.STRING: functional protein association networksMore...STRINGi9606.ENSP00000340132. PTM databasesiPTMnet integrated resource for PTMs in systems biology contextMore...iPTMnetiQ8NA42. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.More...PhosphoSitePlusiQ8NA42. Polymorphism and mutation databasesBioMuta curated single-nucleotide variation and disease association databaseMore...BioMutaiZNF383. Domain mapping of disease mutations (DMDM)More...DMDMi74760056. Proteomic databasesMaxQB - The MaxQuant DataBaseMore...MaxQBiQ8NA42. PaxDb, a database of protein abundance averages across all three domains of lifeMore...PaxDbiQ8NA42. PeptideAtlasMore...PeptideAtlasiQ8NA42. PRoteomics IDEntifications databaseMore...PRIDEiQ8NA42. Protocols and materials databasesThe DNASU plasmid repositoryMore...DNASUi163087. Structural Biology KnowledgebaseSearch...Genome annotation databasesEnsembl eukaryotic genome annotation projectMore...EnsembliENST00000352998; ENSP00000340132; ENSG00000188283. ENST00000589413; ENSP00000464871; ENSG00000188283. ENST00000590503; ENSP00000466101; ENSG00000188283. Database of genes from NCBI RefSeq genomesMore...GeneIDi163087. KEGG: Kyoto Encyclopedia of Genes and GenomesMore...KEGGihsa:163087. UCSC genome browserMore...UCSCiuc002oft.2. human. Organism-specific databasesComparative Toxicogenomics DatabaseMore...CTDi163087. GeneCards: human genes, protein and diseasesMore...GeneCardsiZNF383. Human Gene Nomenclature DatabaseMore...HGNCiHGNC:18609. ZNF383. Human Protein AtlasMore...HPAiHPA063945. neXtProt; the human protein knowledge platformMore...neXtProtiNX_Q8NA42. Open TargetsMore...OpenTargetsiENSG00000188283. The Pharmacogenetics and Pharmacogenomics Knowledge BaseMore...PharmGKBiPA134903145. GenAtlas: human gene databaseMore...GenAtlasiSearch...Phylogenomic databasesevolutionary genealogy of genes: Non-supervised Orthologous GroupsMore...eggNOGiKOG1721. Eukaryota. COG5048. LUCA. Ensembl GeneTreeMore...GeneTreeiENSGT00840000129704. The HOGENOM Database of Homologous Genes from Fully Sequenced OrganismsMore...HOGENOMiHOG000234617. The HOVERGEN Database of Homologous Vertebrate GenesMore...HOVERGENiHBG018163. InParanoid: Eukaryotic Ortholog GroupsMore...InParanoidiQ8NA42. KEGG Orthology (KO)More...KOiK09228. Identification of Orthologs from Complete Genome DataMore...OMAiLEYRNHF. Database of Orthologous GroupsMore...OrthoDBiEOG091G02KC. Database for complete collections of gene phylogeniesMore...PhylomeDBiQ8NA42. Enzyme and pathway databasesBioCyc Collection of Pathway/Genome DatabasesMore...BioCyciZFISH:ENSG00000066263-MONOMER. Reactome - a knowledgebase of biological pathways and processesMore...ReactomeiR-HSA-212436. Generic Transcription Pathway. Miscellaneous databasesDatabase of phenotypes from RNA interference screens in Drosophila and Homo sapiensMore...GenomeRNAii163087. Protein OntologyMore...PROiQ8NA42. Gene expression databasesBgee dataBase for Gene Expression EvolutionMore...BgeeiENSG00000188283. CleanEx database of gene expression profilesMore...CleanExiHS_ZNF383. ExpressionAtlas, Differential and Baseline ExpressionMore...ExpressionAtlasiQ8NA42. baseline and differential. Genevisible search portal to normalized and curated expression data from GenevestigatorMore...GenevisibleiQ8NA42. HS. Family and domain databasesConserved Domains DatabaseMore...CDDicd07765. KRAB_A-box. 1 hit. Gene3D Structural and Functional Annotation of Protein FamiliesMore...Gene3Di3.30.160.60. 11 hits. Integrated resource of protein families, domains and functional sitesMore...InterProiIPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]Pfam protein domain databaseMore...PfamiPF01352. KRAB. 1 hit. PF00096. zf-C2H2. 7 hits. PF13465. zf-H2C2_2. 1 hit. [Graphical view]Simple Modular Architecture Research Tool; a protein domain databaseMore...SMARTiSM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]Superfamily database of structural and functional annotationMore...SUPFAMiSSF109640. SSF109640. 1 hit. PROSITE; a protein domain and family databaseMore...PROSITEiPS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]ProtoNet; Automatic hierarchical classification of proteinsMore...ProtoNetiSearch...
<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN383_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniQ8NA42Primary (citable) accession number: Q8NA42Secondary accession number(s): Q6X2C7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005Last sequence update: October 1, 2002Last modified: November 30, 2016This is version 121 of the entry and version 1 of the sequence. See complete history.
ZNF383 - Zinc finger protein 383 - Homo sapiens (Human) - ZNF383 gene & protein
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(ZN383_HUMAN)Basket 0(max 400 entries)xYour basket is currently empty.Select item(s) and click on "Add to basket" to create your own collection here (400 entries max)UniProtKB (0)UniRef (0)UniParc (0)AlignBLASTMap IdsDownloadFull ViewRemoveClear DisplayEntryPublicationsFeature viewerFeature tableAll NoneFunctionNames & TaxonomySubcellular locationSubcell. locationPathology & BiotechPathol./BiotechPTM / ProcessingExpressionInteractionStructureFamily & DomainsSequenceCross-referencesEntry informationMiscellaneousSimilar proteinsTopBLAST>sp|Q8NA42|ZN383_HUMAN Zinc finger protein 383 OS=Homo sapiens GN=ZNF383 PE=2 SV=1
MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVSMGLYTPKPQVISLLEQ
GKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQREIMGLTKHGLEYSSFGDV
LEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLHQIINNEDRPYECKKCGKAFS
QNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSY
LSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQH
ARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIH
TGEKPYDCKECGKAFTQSSQLRQHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEK
PYECNECGKAFNKCSNLTRHLRIHTGEKPYNCKECGKAFSSGSDLIRHQGIHTNK
AlignFormatAdd to basketAdded to basketHistoryEntry version 121 (30 Nov 2016)Sequence version 1 (01 Oct 2002)Previous versions | rssOther tutorials and videosHelp videoFeedbackProteinZinc finger protein 383GeneZNF383OrganismHomo sapiens (Human)StatusReviewed-Annotation score: Annotation score: 4 out of 5Annotation score:4 out of 5
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>FunctioniMay function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.RegionsFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotation
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotation
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>KeywordsiMolecular functionDNA-bindingBiological processTranscription, Transcription regulationLigandMetal-binding, ZincEnzyme and pathway databasesBioCyc Collection of Pathway/Genome DatabasesMore...BioCyciZFISH:ENSG00000066263-MONOMER. Reactome - a knowledgebase of biological pathways and processesMore...ReactomeiR-HSA-212436. Generic Transcription Pathway. <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the ‘Names and Taxonomy’ section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesiRecommended name:Zinc finger protein 383
<p>This subsection of the ‘Names and taxonomy’ section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesiName:ZNF383ORF Names:HSD17
<p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins. <br></br>These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19 Organism-specific databasesHuman Gene Nomenclature DatabaseMore...HGNCiHGNC:18609. ZNF383. <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationiNucleus 1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Cytoplasm 1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Note: Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenticytoplasm Source: UniProtKB-SubCellnuclear membrane Source: HPAnucleus Source: HPA
<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & BiotechiOrganism-specific databasesOpen TargetsMore...OpenTargetsiENSG00000188283. The Pharmacogenetics and Pharmacogenomics Knowledge BaseMore...PharmGKBiPA134903145. Polymorphism and mutation databasesBioMuta curated single-nucleotide variation and disease association databaseMore...BioMutaiZNF383. Domain mapping of disease mutations (DMDM)More...DMDMi74760056. <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475501 – 475Zinc finger protein 383Add BLAST475Proteomic databasesMaxQB - The MaxQuant DataBaseMore...MaxQBiQ8NA42. PaxDb, a database of protein abundance averages across all three domains of lifeMore...PaxDbiQ8NA42. PeptideAtlasMore...PeptideAtlasiQ8NA42. PRoteomics IDEntifications databaseMore...PRIDEiQ8NA42. PTM databasesiPTMnet integrated resource for PTMs in systems biology contextMore...iPTMnetiQ8NA42. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.More...PhosphoSitePlusiQ8NA42. <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityiExpressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageiIn tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate.1 Publication
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway."Cao L., Wang Z., Zhu C., Zhao Y., Yuan W., Li J., Wang Y., Ying Z., Li Y., Yu W., Wu X., Liu M.Biochem. Biophys. Res. Commun. 333:1050-1059(2005) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.Gene expression databasesBgee dataBase for Gene Expression EvolutionMore...BgeeiENSG00000188283. CleanEx database of gene expression profilesMore...CleanExiHS_ZNF383. ExpressionAtlas, Differential and Baseline ExpressionMore...ExpressionAtlasiQ8NA42. baseline and differential. Genevisible search portal to normalized and curated expression data from GenevestigatorMore...GenevisibleiQ8NA42. HS. Organism-specific databasesHuman Protein AtlasMore...HPAiHPA063945. <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>InteractioniProtein-protein interaction databasesThe Biological General Repository for Interaction Datasets (BioGrid)More...BioGridi127849. 2 interactors.STRING: functional protein association networksMore...STRINGi9606.ENSP00000340132. <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei3D structure databasesProtein Model Portal of the PSI-Nature Structural Biology KnowledgebaseMore...ProteinModelPortaliQ8NA42. SWISS-MODEL Repository - a database of annotated 3D protein structure modelsMore...SMRiQ8NA42. Database of comparative protein structure modelsMore...ModBaseiSearch...MobiDB: a database of protein disorder and mobility annotationsMore...MobiDBiSearch...
<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>DomainiThe KRAB domain is responsible for the transcriptional repressor activity.
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - DomainiRepeat, Zinc-fingerPhylogenomic databasesevolutionary genealogy of genes: Non-su
pervised Orthologous GroupsMore...eggNOGiKOG1721. Eukaryota. COG5048. LUCA. Ensembl GeneTreeMore...GeneTreeiENSGT00840000129704. The HOGENOM Database of Homologous Genes from Fully Sequenced OrganismsMore...HOGENOMiHOG000234617. The HOVERGEN Database of Homologous Vertebrate GenesMore...HOVERGENiHBG018163. InParanoid: Eukaryotic Ortholog GroupsMore...InParanoidiQ8NA42. KEGG Orthology (KO)More...KOiK09228. Identification of Orthologs from Complete Genome DataMore...OMAiLEYRNHF. Database of Orthologous GroupsMore...OrthoDBiEOG091G02KC. Database for complete collections of gene phylogeniesMore...PhylomeDBiQ8NA42. Family and domain databasesConserved Domains DatabaseMore...CDDicd07765. KRAB_A-box. 1 hit. Gene3D Structural and Functional Annotation of Protein FamiliesMore...Gene3Di3.30.160.60. 11 hits. Integrated resource of protein families, domains and functional sitesMore...InterProiIPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]Pfam protein domain databaseMore...PfamiPF01352. KRAB. 1 hit. PF00096. zf-C2H2. 7 hits. PF13465. zf-H2C2_2. 1 hit. [Graphical view]Simple Modular Architecture Research Tool; a protein domain databaseMore...SMARTiSM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]Superfamily database of structural and functional annotationMore...SUPFAMiSSF109640. SSF109640. 1 hit. PROSITE; a protein domain and family databaseMore...PROSITEiPS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.Q8NA42-1 [UniParc]FASTAAdd to basketAdded to basket« Hide        10         20         30         40         50MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP         60         70         80         90        100KPQVISLLEQ GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC        110        120        130        140        150QREIMGLTKH GLEYSSFGDV LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT        160        170        180        190        200FIQQTFLTLH QIINNEDRPY ECKKCGKAFS QNSQFIQHQR IHIGEKSYEC        210        220        230        240        250KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY LSQHQRIHTG        260        270        280        290        300KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH        310        320        330        340        350ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG        360        370        380        390        400SALTNHQRIH TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG        410        420        430        440        450KAFTQNSQLF QHQRIHTDEK PYECNECGKA FNKCSNLTRH LRIHTGEKPY        460        470 NCKECGKAFS SGSDLIRHQG IHTNK                       Show »Length:475Mass (Da):54,613Last modified:October 1, 2002 - v1
Checksum:i2F47070F5C2E582BBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterGOExperimental InfoFeature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11V → A in AAP20067 (Ref. 2) Curated1
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114Y → H in AAP20067 (Ref. 2) Curated1
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti443I → V in AAP20067 (Ref. 2) Curated1Sequence databasesSelect the link destinations:EMBL nucleotide sequence databaseMore...EMBLiGenBank nucleotide sequence databaseMore...GenBankiDNA Data Bank of Japan; a nucleotide sequence databaseMore...DDBJiLinks UpdatedAY438646 mRNA. Translation: AAR14184.1.AY260141 mRNA. Translation: AAP20067.1.AK093182 mRNA. Translation: BAC04086.1.The Consensus CDS (CCDS) projectMore...CCDSiCCDS12501.1. NCBI Reference SequencesMore...RefSeqiNP_689817.1. NM_152604.2. XP_005258642.1. XM_005258585.2. XP_011524888.1. XM_011526586.2. XP_011524889.1. XM_011526587.2. XP_011524890.1. XM_011526588.2. XP_011524891.1. XM_011526589.2. XP_011524892.1. XM_011526590.2. XP_016881911.1. XM_017026422.1. XP_016881912.1. XM_017026423.1. XP_016881913.1. XM_017026424.1. UniGene gene-oriented nucleotide sequence clustersMore...UniGeneiHs.590975. Genome annotation databasesEnsembl eukaryotic genome annotation projectMore...EnsembliENST00000352998; ENSP00000340132; ENSG00000188283. ENST00000589413; ENSP00000464871; ENSG00000188283. ENST00000590503; ENSP00000466101; ENSG00000188283. Database of genes from NCBI RefSeq genomesMore...GeneIDi163087. KEGG: Kyoto Encyclopedia of Genes and GenomesMore...KEGGihsa:163087. UCSC genome browserMore...UCSCiuc002oft.2. human. <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesiSequence databasesSelect the link destinations:EMBL nucleotide sequence databaseMore...EMBLiGenBank nucleotide sequence databaseMore...GenBankiDNA Data Bank of Japan; a nucleotide sequence databaseMore...DDBJiLinks UpdatedAY438646 mRNA. Translation: AAR14184.1.AY260141 mRNA. Translation: AAP20067.1.AK093182 mRNA. Translation: BAC04086.1.The Consensus CDS (CCDS) projectMore...CCDSiCCDS12501.1. NCBI Reference SequencesMore...RefSeqiNP_689817.1. NM_152604.2. XP_005258642.1. XM_005258585.2. XP_011524888.1. XM_011526586.2. XP_011524889.1. XM_011526587.2. XP_011524890.1. XM_011526588.2. XP_011524891.1. XM_011526589.2. XP_011524892.1. XM_011526590.2. XP_016881911.1. XM_017026422.1. XP_016881912.1. XM_017026423.1. XP_016881913.1. XM_017026424.1. UniGene gene-oriented nucleotide sequence clustersMore...UniGeneiHs.590975. 3D structure databasesProtein Model Portal of the PSI-Nature Structural Biology KnowledgebaseMore...ProteinModelPortaliQ8NA42. SWISS-MODEL Repository - a database of annotated 3D protein structure modelsMore...SMRiQ8NA42. Database of comparative protein structure modelsMore...ModBaseiSearch...MobiDB: a database of protein disorder and mobility annotationsMore...MobiDBiSearch...Protein-protein interaction databasesThe Biological General Repository for Interaction Datasets (BioGrid)More...BioGridi127849. 2 interactors.STRING: functional protein association networksMore...STRINGi9606.ENSP00000340132. PTM databasesiPTMnet integrated resource for PTMs in systems biology contextMore...iPTMnetiQ8NA42. Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.More...PhosphoSitePlusiQ8NA42. Polymorphism and mutation databasesBioMuta curated single-nucleotide variation and disease association databaseMore...BioMutaiZNF383. Domain mapping of disease mutations (DMDM)More...DMDMi74760056. Proteomic databasesMaxQB - The MaxQuant DataBaseMore...MaxQBiQ8NA42. PaxDb, a database of protein abundance averages across all three domains of lifeMore...PaxDbiQ8NA42. PeptideAtlasMore...PeptideAtlasiQ8NA42. PRoteomics IDEntifications databaseMore...PRIDEiQ8NA42. Protocols and materials databasesThe DNASU plasmid repositoryMore...DNASUi163087. Structural Biology KnowledgebaseSearch...Genome annotation databasesEnsembl eukaryotic genome annotation projectMore...EnsembliENST00000352998; ENSP00000340132; ENSG00000188283. ENST00000589413; ENSP00000464871; ENSG00000188283. ENST00000590503; ENSP00000466101; ENSG00000188283. Database of genes from NCBI RefSeq genomesMore...GeneIDi163087. KEGG: Kyoto Encyclopedia of Genes and GenomesMore...KEGGihsa:163087. UCSC genome browserMore...UCSCiuc002oft.2. human. Organism-specific databasesComparative Toxicogenomics DatabaseMore...CTDi163087. GeneCards: human genes, protein and diseasesMore...GeneCardsiZNF383. Human Gene Nomenclature DatabaseMore...HGNCiHGNC:18609. ZNF383. Human Protein AtlasMore...HPAiHPA063945. neXtProt; the human protein knowledge platformMore...neXtProtiNX_Q8NA42. Open TargetsMore...OpenTargetsiENSG00000188283. The Pharmacogenetics and Pharmacogenomics Knowledge BaseMore...PharmGKBiPA134903145. GenAtlas: human gene databaseMore...GenAtlasiSearch...Phylogenomic databasesevolutionary genealogy of genes: Non-supervised Orthologous GroupsMore...eggNOGiKOG1721. Eukaryota. COG5048. LUCA. Ensembl GeneTreeMore...GeneTreeiENSGT00840000129704. The HOGENOM Database of Homologous Genes from Fully Sequenced OrganismsMore...HOGENOMiHOG000234617. The HOVERGEN Database of Homologous Vertebrate GenesMore...HOVERGENiHBG018163. InParanoid: Eukaryotic Ortholog GroupsMore...InParanoidiQ8NA42. KEGG Orthology (KO)More...KOiK09228. Identification of Orthologs from Complete Genome DataMore...OMAiLEYRNHF. Database of Orthologous GroupsMore...OrthoDBiEOG091G02KC. Database for complete collections of gene phylogeniesMore...PhylomeDBiQ8NA42. Enzyme and pathway databasesBioCyc Collection of Pathway/Genome DatabasesMore...BioCyciZFISH:ENSG00000066263-MONOMER. Reactome - a knowledgebase of biological pathways and processesMore...ReactomeiR-HSA-212436. Generic Transcription Pathway. Miscellaneous databasesDatabase of phenotypes from RNA interference screens in Drosophila and Homo sapiensMore...GenomeRNAii163087. Protein OntologyMore...PROiQ8NA42. Gene expression databasesBgee dataBase for Gene Expression EvolutionMore...BgeeiENSG00000188283. CleanEx database of gene expression profilesMore...CleanExiHS_ZNF383. ExpressionAtlas, Differential and Baseline ExpressionMore...ExpressionAtlasiQ8NA42. baseline and differential. Genevisible search portal to normalized and curated expression data from GenevestigatorMore...GenevisibleiQ8NA42. HS. Family and domain databasesConserved Domains DatabaseMore...CDDicd07765. KRAB_A-box. 1 hit. Gene3D Structural and Functional Annotation of Protein FamiliesMore...Gene3Di3.30.160.60. 11 hits. Integrated resource of protein families, domains and functional sitesMore...InterProiIPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]Pfam protein domain databaseMore...PfamiPF01352. KRAB. 1 hit. PF00096. zf-C2H2. 7 hits. PF13465. zf-H2C2_2. 1 hit. [Graphical view]Simple Modular Architecture Research Tool; a protein domain databaseMore...SMARTiSM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]Superfamily database of structural and functional annotationMore...SUPFAMiSSF109640. SSF109640. 1 hit. PROSITE; a protein domain and family databaseMore...PROSITEiPS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]ProtoNet; Automatic hierarchical classification of proteinsMore...ProtoNetiSearch...
<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN383_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniQ8NA42Primary (citable) accession number: Q8NA42Secondary accession number(s): Q6X2C7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005Last sequence update: October 1, 2002Last modified: November 30, 2016This is version 121 of the entry and version 1 of the sequence. See complete history.